Fluidized Bed Granulation


In the pharmaceutical industry, granulation refers to the act or process in which primary powder particles are made to adhere to form larger, multi-particle entities called granules. Granules typically have a size range between 0.2 to 4.0 mm depending on their subsequent use. It is the process of collecting particles together by creating bonds between them. Bonds are formed by compression or by using a binding agent. Granulation is extensively used in the manufacturing of tablets and pellets (or spheroids).

Why to granulate?

  • To prevent segregation of the constituents of the powder mix or to improve content uniformity
  • To reduce the dust content present in powders
  • To improve flow properties of the mix
  • To improve the compaction characteristics and compressibility of the mix
  • To enhance disintegration and dissolution

Possible Batch Sizes

ACG Pharma Technologies offers equipment sizes starting from FBE 25 till FBE 1300. Thus, selection of correct size of the equipment can ensure that the desired batch size can be selected. The lowest batch size for any product container will be 40% of the product bowl capacity. For example, FBE 125 product container size is 125 litre and thus, lowest batch size will be 125 x 40% = 48 litres. If the average bulk density of the starting material is considered as 0.5 gm/cc, then the lowest batch size will be 24 kg and the highest batch size will be almost 100% volume of the product container, which can be as high as 60 kgs.

For products related to fluid bed granulation